Elastin and Elastase
نویسندگان
چکیده
منابع مشابه
Neutrophil elastase-induced elastin degradation mediates macrophage
23 Neutrophil (PMNL) influx precedes lung macrophage (LM) influx into the lung following 24 exposure of newborn pups to 60% O2. We hypothesized that PMNL were responsible for the 25 signals leading to LM influx. This was confirmed when inhibition of PMNL influx with a CXC 26 chemokine receptor-2 antagonist, SB-265610, also prevented the 60% O2-dependent LM influx, 27 LM-derived nitrotyrosine fo...
متن کاملStudies on elastase and elastin. I. Assay and properties of elastase.
As early as 1890, Ewald (1) showed that extracts of pancreas were able to dissolve the elastic fibers of connective tissue. In 1950, Balo and Banga (2) described the properties of a purified enzyme obtained from defatted pancreatic powder, distinct from trypsin and chymotrypsin, and capable of dissolving elastic fibers either in tissues or in test tubes. Lewis, Williams, and Brink (3) have sinc...
متن کاملThe cell-elastin-elastase(s) interacting triade directs elastolysis.
Human elastases have been identified within serine, cysteine and metallopeptidase families. These enzymes are able to adsorb rapidly onto elastin, but they can also bind onto cell surface-associated proteins such as heparan sulfate proteoglycans, both interactions involving enzyme exosites distinct form active site. Immobilization of elastin at the cell surface will create a sequestered microen...
متن کاملStudies on elastase and elastin. II. Partial purification and properties of activation of proelastase.
Elastase is a proteolytic enzyme that hydrolyzes the peptide bonds of elastin (1, 2). It was puzzling to early investigators that elastase activity could be demonstrated only with difficulty, if at all, in fresh extracts of pancreas or pancreatic juice (3, 4), although it was readily extracted from dried, defatted, powdered pancreas. In 1955 Grant and Robbins (5, 6) clarified this phenomenon by...
متن کاملEffects of elastase on the mechanical and failure properties of engineered elastin-rich matrices.
Pulmonary emphysema and vessel wall aneurysms are diseases characterized by elastolytic damage to elastin fibers that leads to mechanical failure. To model this, neonatal rat aortic smooth muscle cells were cultured, accumulating an extracellular matrix rich in elastin, and mechanical measurements were made before and during enzymatic digestion of elastin. Specifically, the cells in the culture...
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ژورنال
عنوان ژورنال: Nature
سال: 1965
ISSN: 0028-0836,1476-4687
DOI: 10.1038/205938a0